What is finerenone mechanism of action?

Finerenone is a selective nonsteroidal mineralocorticoid receptor antagonist that behaves as an antagonist of the mineralocorticoid receptor. This means that it binds to the mineralocorticoid receptor, allowing it to block the action of aldosterone and its signaling pathway. Aldosterone is a natural hormone that plays a vital role in regulating electrolyte and water balance in the body.

Finerenone works by blocking aldosterone effects in several organs, including the kidneys, heart, and blood vessels. The drug increases sodium and water excretion while decreasing potassium excretion, leading to reduced sodium, water retention, and decreased blood pressure. By blocking the activity of aldosterone, Finerenone also reduces fibrosis and inflammation in the kidneys and heart.

Finerenone has been shown to be effective in treating a variety of cardiovascular diseases, including heart failure and chronic kidney disease. Its mechanism of action is different from other drugs that are currently available for treating these conditions. By acting as a selective nonsteroidal mineralocorticoid receptor antagonist, Finerenone provides a new and promising approach to treating these diseases.